Human Immunodeficiency Virus (HIV) Type 1 Proviral Hypermutation Correlates with CD4 Count in HIV-Infected Women from Kenya

APOBEC3G is an important innate immune molecule that causes human immunodeficiency virus type 1 (HIV-1) hypermutation, which can result in detrimental viral genome mutations. The Vif protein of wild-type HIV-1 counteracts APOBEC3G activity by targeting it for degradation and inhibiting its incorpora...

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Bibliographic Details
Main Authors: Land, Allison M., Ball, T. Blake, Luo, Ma, Pilon, Richard, Sandstrom, Paul, Embree, Joanne E., Wachihi, Charles, Kimani, Joshua, Plummer, Francis A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519552/
https://ncbi.nlm.nih.gov/pubmed/18550667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01115-08
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