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Drug Resistance Mutations in HIV Provirus are Associated with Defective Proviral Genomes with Hypermutation

BACKGROUND: HIV proviral sequencing overcomes the limit of plasma viral load requirement by detecting all the “archived mutations”, but the clinical relevance remains to be evaluated. METHODS: We included 25 participants with available proviral sequences (both intact and defective sequences availabl...

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Detalhes bibliográficos
Publicado no:AIDS
Main Authors: Li, Yijia, Etemad, Behzad, Dele-Oni, Ruth, Sharaf, Radwa, Gao, Ce, Lichterfeld, Mathias, Li, Jonathan Z
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102365/
https://ncbi.nlm.nih.gov/pubmed/33635848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002850
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