A Mycobacterium tuberculosis Rpf Double-Knockout Strain Exhibits Profound Defects in Reactivation from Chronic Tuberculosis and Innate Immunity Phenotypes

Resuscitation-promoting factors (Rpfs), apparent peptidoglycan hydrolases, have been implicated in the reactivation of dormant bacteria. We previously demonstrated that deletion of rpfB impaired reactivation of Mycobacterium tuberculosis in a mouse model. Because M. tuberculosis encodes five Rpf par...

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Hlavní autoři: Russell-Goldman, Eleanor, Xu, Jiayong, Wang, Xiaobing, Chan, John, Tufariello, JoAnn M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519441/
https://ncbi.nlm.nih.gov/pubmed/18591237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01735-07
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