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Influenza Virus Vaccination Induces Interleukin-12/23 Receptor β1 (IL-12/23Rβ1)-Independent Production of Gamma Interferon (IFN-γ) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23Rβ1 or IFN-γ Receptor I

To investigate whether protective immune responses can be induced in the absence of normal interleukin-12/23/gamma interferon (IL-12/23/IFN-γ) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor β1 (IL-12/23Rβ1) deficiencies, t...

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Autors principals: de Boer, Tjitske, van Dissel, Jaap T., Kuijpers, Taco W. J., Rimmelzwaan, Guus F., Kroon, Frank P., Ottenhoff, Tom H. M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519311/
https://ncbi.nlm.nih.gov/pubmed/18562567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00090-08
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