The cAMP-activated GTP exchange factor, Epac1 Upregulates Plasma Membrane and Nuclear Akt Kinase Activities in 8-CPT-2-O-Me-cAMP-Stimulated Macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages*

cAMP regulates a wide range of processes through its downstream effectors including PKA, and the family of guanine nucleotide exchange factors. Depending on the cell type, cAMP inhibits or stimulates growth and proliferation in a PKA-dependent or independent manner. PKA-independent effects are media...

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Bibliografiska uppgifter
Huvudupphovsmän: Misra, Uma K., Kaczowka, Steven, Pizzo, Salvatore V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519236/
https://ncbi.nlm.nih.gov/pubmed/18495429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.04.002
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