Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia

Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, has been proposed to be a mediator of vascular dysfunction during hyperhomocysteinemia. Levels of ADMA are regulated by dimethylarginine dimethylaminohydrolase (DDAH). Using both in vitro and in vivo approache...

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Main Authors: Dayal, Sanjana, Rodionov, Roman N., Arning, Erland, Bottiglieri, Teodoro, Kimoto, Masumi, Murry, Daryl J., Cooke, John P., Faraci, Frank M., Lentz, Steven R.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2008
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519228/
https://ncbi.nlm.nih.gov/pubmed/18567702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01348.2007
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