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Structural Modifications of ICAM-1 Cyclic Peptides to Improve the Activity to Inhibit Heterotypic Adhesion of T cells

LFA-1/ICAM-1 interaction plays an important role in the formation of the immunological synapse between T cells and antigen-presenting cells (APC). Blocking of LFA-1/ICAM-1 interactions has been shown to suppress the progression of autoimmune diseases. cIBR peptide (cyclo(1,12)PenPRGGSVLVTGC) inhibit...

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Bibliografiske detaljer
Main Authors: Iskandarsyah, Tejo, Bimo A., Tambunan, Usman S. F., Verkhivker, Gennady, Siahaan, Teruna J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519170/
https://ncbi.nlm.nih.gov/pubmed/18554252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00676.x
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