Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis

The atypical PKC-interacting protein, Par-4, inhibits cell survival and tumorigenesis in vitro, and its genetic inactivation in mice leads to reduced lifespan, enhanced benign tumour development and low-frequency carcinogenesis. Here, we demonstrate that Par-4 is highly expressed in normal lung but...

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Bibliografiske detaljer
Main Authors: Joshi, Jayashree, Fernandez-Marcos, Pablo J, Galvez, Anita, Amanchy, Ramars, Linares, Juan F, Duran, Angeles, Pathrose, Peterson, Leitges, Michael, Cañamero, Marta, Collado, Manuel, Salas, Clara, Serrano, Manuel, Moscat, Jorge, Diaz-Meco, Maria T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519103/
https://ncbi.nlm.nih.gov/pubmed/18650932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.149
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