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Isotope Effects on the Enzymatic and Non-Enzymatic Reactions of Chorismate

The important biosynthetic intermediate chorismate reacts thermally by two competitive pathways, one leading to 4-hydroxybenzoate via elimination of the enolpyruvyl side chain, and the other to prephenate by a facile Claisen rearrangement. Measurements with isotopically labeled chorismate derivative...

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Bibliographic Details
Main Authors: Wright, S. Kirk, DeClue, Michael S., Mandal, Ajay, Lee, Lac, Wiest, Olaf, Cleland, W. Wallace, Hilvert, Donald
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519010/
https://ncbi.nlm.nih.gov/pubmed/16159290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja052929v
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