Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied

When the spindle assembly checkpoint (SAC) cannot be satisfied, cells exit mitosis via mitotic slippage. In microtubule (MT) poisons, slippage requires cyclin B proteolysis, and it appears to be accelerated in drug concentrations that allow some MT assembly. To determine if MTs accelerate slippage,...

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Bibliographic Details
Main Authors: Brito, Daniela A., Yang, Zhenye, Rieder, Conly L.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518701/
https://ncbi.nlm.nih.gov/pubmed/18710927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200805072
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