CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats

BACKGROUND AND PURPOSE: MP4 (Hemospan) is a Hb-based oxygen therapeutic agent, based on polyethylene-glycol (PEG) conjugation to Hb, undergoing clinical trials as an oxygen carrier. This study describes the functional interaction between MP4 and carbon monoxide (CO), as a CO delivery agent, and the...

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Hlavní autoři: Vandegriff, K D, Young, M A, Lohman, J, Bellelli, A, Samaja, M, Malavalli, A, Winslow, R M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518471/
https://ncbi.nlm.nih.gov/pubmed/18536756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.219
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