Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates

Haemoglobin-based oxygen carriers can undergo oxidation of ferrous haemoglobin into a non-functional ferric form with enhanced rates of haem loss. A recently developed human haemoglobin conjugated to maleimide-activated poly(ethylene glycol), termed MP4, has unique physicochemical properties (increa...

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Detalhes bibliográficos
Main Authors: Vandegriff, Kim D., Malavalli, Ashok, Minn, Charles, Jiang, Eva, Lohman, Jeff, Young, Mark A., Samaja, Michele, Winslow, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615902/
https://ncbi.nlm.nih.gov/pubmed/16813564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060809
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