Activation of peroxisome proliferator-activated receptor-α in mice induces expression of the hepatic low-density lipoprotein receptor

BACKGROUND AND PURPOSE: Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolaemia in humans and deletion of the LDLR induces lesion development in mice fed a high-fat diet. LDLR expression is predominantly regulated by sterol regulatory element-binding protei...

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Detalhes bibliográficos
Main Authors: Huang, Z, Zhou, X, Nicholson, A C, Gotto, A M, Hajjar, D P, Han, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518458/
https://ncbi.nlm.nih.gov/pubmed/18852694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.331
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