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HIV Integrase Inhibitors with Nucleobase Scaffolds: Discovery of a Highly Potent anti-HIV Agent

HIV integrase is essential for HIV replication. However, there are currently no integrase inhibitors in clinical use for AIDS. We have discovered a conceptually new β-diketo acid that is a powerful inhibitor of both the 3′-processing and strand transfer steps of HIV-1 integrase. The in vitro anti-HI...

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Detaylı Bibliyografya
Asıl Yazarlar: Nair, Vasu, Chi, Guochen, Ptak, Roger, Neamati, Nouri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518396/
https://ncbi.nlm.nih.gov/pubmed/16420027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0508890
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