Discovery of a Potent HIV Integrase Inhibitor That Leads to a Prodrug with Significant anti-HIV Activity

[Image: see text] Worldwide research efforts in drug discovery involving HIV integrase have produced only one compound, raltegravir, that has been approved for clinical use in HIV/AIDS. As resistance, toxicity, and drug–drug interactions are recurring issues with all classes of anti-HIV drugs, the d...

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Hlavní autoři: Seo, Byung I., Uchil, Vinod R., Okello, Maurice, Mishra, Sanjay, Ma, Xiao-Hui, Nishonov, Malik, Shu, Qingning, Chi, Guochen, Nair, Vasu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274775/
https://ncbi.nlm.nih.gov/pubmed/22328963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2001246
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