Analysis of HIV-1 CRF_01 A/E Protease Inhibitor Resistance: Structural determinants for maintaining sensitivity and developing resistance to atazanavir

A series of HIV-1 protease mutants have been designed to analyze the contribution to drug resistance provided by natural polymorphisms as well as therapy-selective (active and non-active site) mutations in the HIV-1 CRF_01 A/E (AE) protease when compared to the subtype-B (B) protease. Kinetic analys...

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Main Authors: Clemente, José C., Coman, Roxana M., Thiaville, Michele M., Janka, Linda K., Jeung, Jennifer A., Nukoolkarn, Sarawut, Govindasamy, Lakshmanan, Agbandje-McKenna, Mavis, McKenna, Robert, Leelamanit, Wichet, Goodenow, Maureen M., Dunn, Ben M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518317/
https://ncbi.nlm.nih.gov/pubmed/16634628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051886s
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