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Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential
Mild uncoupling of oxidative phosphorylation, caused by a leak of protons back into the matrix, limits mitochondrial production of ROS (reactive oxygen species). This proton leak can be induced by the lipid peroxidation products of ROS, such as HNE (4-hydroxynonenal). HNE activates uncoupling protei...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Portland Press Ltd.
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518262/ https://ncbi.nlm.nih.gov/pubmed/18384278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20080002 |
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