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Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential
Mild uncoupling of oxidative phosphorylation, caused by a leak of protons back into the matrix, limits mitochondrial production of ROS (reactive oxygen species). This proton leak can be induced by the lipid peroxidation products of ROS, such as HNE (4-hydroxynonenal). HNE activates uncoupling protei...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Portland Press Ltd.
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518262/ https://ncbi.nlm.nih.gov/pubmed/18384278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20080002 |
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