Binomial Mitotic Segregation of MYCN-Carrying Double Minutes in Neuroblastoma Illustrates the Role of Randomness in Oncogene Amplification

BACKGROUND: Amplification of the oncogene MYCN in double minutes (DMs) is a common finding in neuroblastoma (NB). Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development. PRINCIPAL FINDINGS: We show that MYCN-c...

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Détails bibliographiques
Auteurs principaux: Lundberg, Gisela, Rosengren, Anders H., Håkanson, Ulf, Stewénius, Henrik, Jin, Yuesheng, Stewénius, Ylva, Påhlman, Sven, Gisselsson, David
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518122/
https://ncbi.nlm.nih.gov/pubmed/18769732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003099
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