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Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

Phosphatidylinositol 3-OH kinase (PI3K) has been widely studied as a principal regulator of cell polarization, migration, and chemotaxis [1], [2], [3], [4]. Surprisingly, recent studies showed that mammalian neutrophils and Dictyostelium discoideum cells can polarize and migrate in the absence of PI...

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Bibliografske podrobnosti
Main Authors: Inoue, Takanari, Meyer, Tobias
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518103/
https://ncbi.nlm.nih.gov/pubmed/18728784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003068
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