Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and β-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat

The Zucker Diabetic Fatty (ZDF) rat is a model of impaired insulin sensitivity arising from hyperphagia owing to a mutation in the leptin receptor. In time, young ZDF rats, which are not initially diabetic, develop impaired pancreatic β-cell function leading to apoptotic cell death. This results in...

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Bibliografiske detaljer
Main Authors:	Pickavance, Lucy C, Widdowson, Peter S, Foster, John R, Williams, Gareth, Wilding, John P H
Format:	Artigo
Sprog:	Inglês
Udgivet:	Blackwell Science Inc 2003
Fag:	Original Articles
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2517543/ https://ncbi.nlm.nih.gov/pubmed/12801282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2613.2003.00337.x
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Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and β-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat

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