Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and β-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat

The Zucker Diabetic Fatty (ZDF) rat is a model of impaired insulin sensitivity arising from hyperphagia owing to a mutation in the leptin receptor. In time, young ZDF rats, which are not initially diabetic, develop impaired pancreatic β-cell function leading to apoptotic cell death. This results in...

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Главные авторы: Pickavance, Lucy C, Widdowson, Peter S, Foster, John R, Williams, Gareth, Wilding, John P H
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2003
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517543/
https://ncbi.nlm.nih.gov/pubmed/12801282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2613.2003.00337.x
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