Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy

The role of cathepsin L in normal physiological processes was assessed using cathepsin L homozygous knockout mice (B6;129-Ctsl(tm1Alpk)). These mice were generated using gene targeting in embryonic stem cells. Null mice fail to express mRNA and protein to cathepsin L. They developed normally and wer...

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Bibliografski detalji
Glavni autori: Potts, Wendy, Bowyer, Jonathan, Jones, Huw, Tucker, David, Freemont, Anthony J, Millest, Andrew, Martin, Colin, Vernon, Wendy, Neerunjun, Diane, Slynn, Gillian, Harper, Fiona, Maciewicz, Rose
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2004
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517461/
https://ncbi.nlm.nih.gov/pubmed/15154914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.0959-9673.2004.00373.x
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