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Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats

Injection of the neurotoxin saporin–substance P (SSP-SAP) into the retrotrapezoid nucleus (RTN) attenuates the central chemoreflex in rats. Here we ask whether these deficits are caused by the destruction of a specific type of interneuron that expresses the transcription factor Phox2b and is non-cat...

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Autori principali: Takakura, Ana C, Moreira, Thiago S, Stornetta, Ruth L, West, Gavin H, Gwilt, Justin M, Guyenet, Patrice G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517201/
https://ncbi.nlm.nih.gov/pubmed/18440993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.153163
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