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Mutations in PRP43 that uncouple RNA-dependent NTPase Activity and pre-mRNA Splicing Function

Saccharomyces cerevisiae Prp43 is a DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome. Previous studies identified mutations in Prp43 motifs I, II and VI that were lethal in vivo and ablated ATP hydrolysis in vitro. Such Prp43 mutants exerted...

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Main Authors: Tanaka, Naoko, Schwer, Beate
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517181/
https://ncbi.nlm.nih.gov/pubmed/16700561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052656g
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