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Mutations in PRP43 that uncouple RNA-dependent NTPase Activity and pre-mRNA Splicing Function
Saccharomyces cerevisiae Prp43 is a DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome. Previous studies identified mutations in Prp43 motifs I, II and VI that were lethal in vivo and ablated ATP hydrolysis in vitro. Such Prp43 mutants exerted...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517181/ https://ncbi.nlm.nih.gov/pubmed/16700561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052656g |
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