A Pharmacophore Derived Phenytoin Analogue With Increased Affinity For Slow Inactivated Sodium Channels Exhibits A Desired Anticonvulsant Profile

Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We have developed a novel hydantoin compound (HA) using comparative molecular field analysis (CoMFA) and evaluated its effects on hNa(v)1.2 channels. Both DPH and HA demonstrate...

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Bibliografiske detaljer
Main Authors: Lenkowski, Paul W., Batts, Timothy W., Smith, Misty, Ko, Seong-Hoon, Jones, Paulianda J., Taylor, Catherine H., McCusker, Ashley K., Davis, Gary C., Hartmann, Hali A., White, H. Steve, Brown, Milton L., Patel, Manoj K.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517177/
https://ncbi.nlm.nih.gov/pubmed/17174360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2006.11.001
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