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Rational design of new binding specificity by simultaneous mutagenesis of calmodulin and a target peptide
Calcium-saturated calmodulin (CaM) binds and influences the activity of a varied collection of target proteins in most cells. This promiscuity underlies CaM's role as a shared participant in calcium-dependent signal transduction pathways, but imposes a handicap on popular CaM-based calcium bios...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517080/ https://ncbi.nlm.nih.gov/pubmed/17029410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060857u |
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