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Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
Mutations affecting NPM1 (nucleophosmin) are the most common genetic lesions found in acute myeloid leukemia (AML). NPM1 is one of the most abundant proteins found in the nucleolus and has links to the MDM2/p53 tumor suppressor pathway. A distinctive feature of NPM1 mutants in AML is their aberrant...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516977/ https://ncbi.nlm.nih.gov/pubmed/18511415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801706200 |
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