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Exchangeable Models of Complex Inherited Diseases

A model of unlinked diallelic loci affecting the risk of a complex inherited disease is explored. The loci are equivalent in their effect on disease risk and are in Hardy–Weinberg and linkage equilibrium. The goal is to determine what assumptions about dependence of disease risk on genotype are cons...

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Detalhes bibliográficos
Autor principal: Slatkin, Montgomery
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516095/
https://ncbi.nlm.nih.gov/pubmed/18689899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.077719
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