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Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease
Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR). Humans with AID mutations develop not only the autosomal recessive form of hyper-IgM syndrome (HIGM2) associated with B cell hy...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515643/ https://ncbi.nlm.nih.gov/pubmed/18716662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003033 |
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