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Characterization of SpnQ from the Spinosyn Biosynthetic Pathway of Saccharopolyspora spinosa: Mechanistic and Evolutionary Implications for C-3 Deoxygenation in Deoxysugar Biosynthesis

The C-3 deoxygenation step in the biosynthesis of D-forosamine (4-N,N-dimethylamino-2,3,4,6-tetradeoxy-D-threo-hexopyranose), a constituent of spinosyn produced by Saccharopolyspora spinosa, was investigated. The spnQ gene, proposed to encode a TDP-4-keto-2,6-dideoxy-D-glucose 3-dehydratase was clon...

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Hlavní autoři: Hong, Lin, Zhao, Zongbao, Liu, Hung-wen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515268/
https://ncbi.nlm.nih.gov/pubmed/17076492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0649670
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