Vorinostat inhibits STAT6-mediated T(H)2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines

Epigenetic changes have been implicated in silencing several B-cell genes in Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma (HL), and this mechanism has been proposed to promote HRS survival and escape from immunosurveillance. However, the molecular and functional consequences of histone...

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Detalhes bibliográficos
Main Authors: Buglio, Daniela, Georgakis, Georgios V., Hanabuchi, Shino, Arima, Kazuhiko, Khaskhely, Noor M., Liu, Yong-Jun, Younes, Anas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515130/
https://ncbi.nlm.nih.gov/pubmed/18541724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-133769
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