Distinct Effects on Splicing of Two Monoclonal Antibodies Directed against the Amino-terminal Domain of Galectin-3

Previous experiments had established that galectin-3 (Gal3) is a factor involved in cell-free splicing of pre-mRNA. Addition of monoclonal antibody NCL-GAL3, whose epitope maps to the NH(2)-terminal 14 amino acids of Gal3, to a splicing competent nuclear extract inhibited the splicing reaction. In c...

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Bibliographic Details
Main Authors: Gray, Richard M., Davis, Michael J., Ruby, Katherine M., Voss, Patricia G., Patterson, Ronald J., Wang, John L.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515097/
https://ncbi.nlm.nih.gov/pubmed/18455493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.04.010
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