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Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-l-type Ca(2+) channel

The activity of l-type Ca(2+) channels is increased by dihydropyridine (DHP) agonists and inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. These drugs bind to the pore-forming α(1) subunits of l-type Ca(2+) channels. To define the minimal requirements for...

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Autori principali: Hockerman, Gregory H., Peterson, Blaise Z., Sharp, Elizabeth, Tanada, Timothy N., Scheuer, Todd, Catterall, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC25136/
https://ncbi.nlm.nih.gov/pubmed/9405712
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