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Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-l-type Ca(2+) channel
The activity of l-type Ca(2+) channels is increased by dihydropyridine (DHP) agonists and inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. These drugs bind to the pore-forming α(1) subunits of l-type Ca(2+) channels. To define the minimal requirements for...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences of the USA
1997
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC25136/ https://ncbi.nlm.nih.gov/pubmed/9405712 |
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