Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide

Neuronal nitric oxide synthase (nNOS) generates NO in neurons, and heme-oxygenase-2 (HO-2) synthesizes carbon monoxide (CO). We have evaluated the roles of NO and CO in intestinal neurotransmission using mice with targeted deletions of nNOS or HO-2. Immunohistochemical analysis demonstrated colocali...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zakhary, Randa, Poss, Kenneth D., Jaffrey, Samie R., Ferris, Christopher D., Tonegawa, Susumu, Snyder, Solomon H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25126/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405702/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14848
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