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r-VKORC1 expression in factor IX BHK cells increases factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate limiting step

Carboxylation of vitamin K-dependent (VKD) proteins is required for their activity and depends upon reduced vitamin K generated by vitamin K oxidoreductase (VKOR) and a redox protein that regenerates VKOR activity. VKD protein carboxylation is inefficient in mammalian cells, and to understand why ca...

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Detalhes bibliográficos
Main Authors: Hallgren, Kevin W., Qian, Wen, Yakubenko, Anna V., Runge, Kurt W., Berkner, Kathleen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2512261/
https://ncbi.nlm.nih.gov/pubmed/16634640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051986y
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