The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration.
The purified integration protein (IN) of avian myeloblastosis virus is shown to nick double-stranded oligodeoxynucleotide substrates that mimic the ends of the linear form of viral DNA. In the presence of Mg2+, nicks are created 2 nucleotides from the 3' OH ends of both the U5 plus strand and the U3...
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| Udgivet i: | J Virol |
|---|---|
| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1989
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC251198/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2555556/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.12.5319-5327.1989 |
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