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CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain

Brain capillary endothelial cells (BCECs) are targets of CD4-independent infection by HIV-1 and simian immunodeficiency virus (SIV) strains in vitro and in vivo. Infection of BCECs may provide a portal of entry for the virus into the central nervous system and could disrupt blood–brain barrier funct...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Edinger, Aimee L., Mankowski, Joseph L., Doranz, Benjamin J., Margulies, Barry J., Lee, Benhur, Rucker, Joseph, Sharron, Matthew, Hoffman, Trevor L., Berson, Joanne F., Zink, M. Christine, Hirsch, Vanessa M., Clements, Janice E., Doms, Robert W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25107/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405683/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14742
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