Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

Natriuretic peptides, produced in the heart, bind to the natriuretic peptide receptor A (NPRA) and cause vasodilation and natriuresis important in the regulation of blood pressure. We here report that mice lacking a functional Npr1 gene coding for NPRA have elevated blood pressures and hearts exhibi...

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Autores principales: Oliver, Paula M., Fox, Jennifer E., Kim, Ron, Rockman, Howard A., Kim, Hyung-Suk, Reddick, Robert L., Pandey, Kailash N., Milgram, Sharon L., Smithies, Oliver, Maeda, Nobuyo
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC25105/
https://ncbi.nlm.nih.gov/pubmed/9405681
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