Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression.

A method is described for the production of recombinant adeno-associated virus (AAV) stocks that contain no detectable wild-type helper AAV. The recombinant viruses contained only the terminal 191 nucleotides of the AAV chromosome bracketing a nonviral marker gene. trans-Acting AAV functions were pr...

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Argitaratua izan da:	J Virol
Egile Nagusiak:	Samulski, R J, Chang, L S, Shenk, T
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 1989
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2547998/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.9.3822-3828.1989
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