Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.

The human parvovirus adeno-associated virus (AAV) is unique in its ability to target viral integration to a specific site on chromosome 19 (ch-19). Recombinant AAV (rAAV) vectors retain the ability to integrate but have apparently lost this ability to target. In this report, we characterize the term...

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Bibliografiske detaljer
Main Authors: Yang, C C, Xiao, X, Zhu, X, Ansardi, D C, Epstein, N D, Frey, M R, Matera, A G, Samulski, R J
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC230226/
https://ncbi.nlm.nih.gov/pubmed/9371582
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