The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation.

Previous experiments have demonstrated that adenovirus infection of human and mouse cells leads to an E1A-dependent activation of the DNA-binding capacity of a cellular transcription factor termed E2F. E2F binds to two sites in the adenovirus E2 early promoter which have been shown to be critical fo...

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Pubblicato in:	J Virol
Autori principali:	Reichel, R, Neill, S D, Kovesdi, I, Simon, M C, Raychaudhuri, P, Nevins, J R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250954/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2527310/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.9.3643-3650.1989
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