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The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation.

Previous experiments have demonstrated that adenovirus infection of human and mouse cells leads to an E1A-dependent activation of the DNA-binding capacity of a cellular transcription factor termed E2F. E2F binds to two sites in the adenovirus E2 early promoter which have been shown to be critical fo...

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Dettagli Bibliografici
Autori principali: Reichel, R, Neill, S D, Kovesdi, I, Simon, M C, Raychaudhuri, P, Nevins, J R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1989
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC250954/
https://ncbi.nlm.nih.gov/pubmed/2527310
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