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A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.

We have generated and characterized a deletion mutant of herpes simplex virus type-1, dlLAT1.8, which lacks the putative promoter region, transcriptional start site, and 1,015 base pairs of the DNA sequences specifying the latency-associated transcripts (LATs). When tested in a CD-1 mouse ocular mod...

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Published in:J Virol
Main Authors: Leib, D A, Bogard, C L, Kosz-Vnenchak, M, Hicks, K A, Coen, D M, Knipe, D M, Schaffer, P A
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1989
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250836/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2542601/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.7.2893-2900.1989
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