The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53.

The large T antigen encoded by simian virus 40 (SV40) plays essential roles in the infection of permissive cells, leading to production of progeny virions, and in the infection of nonpermissive cells, leading to malignant transformation. Primary mouse embryo fibroblasts (MEFs) are nonpermissive for...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Zhu, J Y, Abate, M, Rice, P W, Cole, C N
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.12.6872-6880.1991
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