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Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation.

Introduction of simian virus 40 T antigen into rodent fibroblasts gives rise to cells that can proliferate indefinitely but are dependent upon it for maintenance of their growth once the normal mitotic life span has elapsed. Inactivation of T antigen in these immortalized cells causes rapid and irre...

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Published in:Mol Cell Biol
Main Authors: Gonos, E S, Burns, J S, Mazars, G R, Kobrna, A, Riley, T E, Barnett, S C, Zafarana, G, Ludwig, R L, Ikram, Z, Powell, A J, Jat, P S
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231513/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8756670/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.9.5127
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