Cytokine-mediated enhancement of epidermal growth factor receptor expression provides an immunological approach to the therapy of pancreatic cancer

Eitemau Tebyg

• Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells.
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• Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases
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• Detection of the anti-p53 antibody response in malignant and benign pancreatic disease.
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• Inverse regulation of human ERBB2 and epidermal growth factor receptors by tumor necrosis factor alpha.
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• Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker.
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