Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines.

Clinical studies previously demonstrated that live influenza A virus vaccines derived by genetic reassortment from the mating of influenza A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) donor virus with epidemic wild-type influenza A viruses are reproducibly safe, infectious, immunogenic, and efficacious...

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Pubblicato in:	J Virol
Autori principali:	Snyder, M H, Betts, R F, DeBorde, D, Tierney, E L, Clements, M L, Herrington, D, Sears, S D, Dolin, R, Maassab, H F, Murphy, B R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250559/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3336068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.2.488-495.1988
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