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Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

E2a-Pbx1 is a chimeric transcription factor oncoprotein produced by the t(1;19) translocation in human pre-B cell leukemia. Class I Hox proteins bind DNA cooperatively with both Pbx proteins and oncoprotein E2a-Pbx1, suggesting that leukemogenesis by E2a-Pbx1 and Hox proteins may alter transcription...

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Bibliografiska uppgifter
Huvudupphovsmän: Knoepfler, Paul S., Calvo, Katherine R., Chen, Haiming, Antonarakis, Stylianos E., Kamps, Mark P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC25052/
https://ncbi.nlm.nih.gov/pubmed/9405651
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