Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

High lactate generation and low glucose oxidation, despite normal oxygen conditions, are commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this altered metabolic phenotype has long been correlated with malignant progression and poor clinical outcome. However, the me...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McFate, Thomas, Mohyeldin, Ahmed, Lu, Huasheng, Thakar, Jay, Henriques, Jeremy, Halim, Nader D., Wu, Hong, Schell, Michael J., Tsang, Tsz Mon, Teahan, Orla, Zhou, Shaoyu, Califano, Joseph A., Jeoung, Nam Ho, Harris, Robert A., Verma, Ajay
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Metabolism and Bioenergetics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504897/
https://ncbi.nlm.nih.gov/pubmed/18541534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801765200
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