Tyrosine Phosphorylation Modifies Protein Kinase C δ-dependent Phosphorylation of Cardiac Troponin I

Our study identifies tyrosine phosphorylation as a novel protein kinase Cδ (PKCδ) activation mechanism that modifies PKCδ-dependent phosphorylation of cardiac troponin I (cTnI), a myofilament regulatory protein. PKCδ phosphorylates cTnI at Ser(23)/Ser(24) when activated by lipid cofactors; Src phosp...

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Autors principals: Sumandea, Marius P., Rybin, Vitalyi O., Hinken, Aaron C., Wang, Chaojian, Kobayashi, Tomoyoshi, Harleton, Erin, Sievert, Gail, Balke, C. William, Feinmark, Steven J., Solaro, R. John, Steinberg, Susan F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504892/
https://ncbi.nlm.nih.gov/pubmed/18550549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802396200
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